Effect-Directed Analysis as a tool for the identification of chemicals of emerging concern

Effect-Directed Analysis (EDA) integrates bioassay testing, sample fractionation and high resolution mass spectrometric (HRMS) identification of pollutants in a variety of (environmental) matrices. EDA has a long tradition but its power was not fully appreciated due to lack of throughput and identification success rate. Recent technological developments such as the implementation of HRMS-equipment have significantly contributed to the further maturation of EDA. In this presentation, examples will be given of the combination of bioassay testing and chemical analysis, focusing on novel fractionation strategies, miniaturized bioassays and the use of compound libraries for the identification of emerging pollutants.

Effect-Directed Analysis (EDA) integrates bioassay testing, sample fractionation and high resolution mass spectrometric (HRMS) identification of pollutants in a variety of (environmental) matrices. EDA has a long tradition but its power was not fully appreciated due to lack of throughput and identification success rate. Recent technological developments such as the implementation of HRMS-equipment have significantly contributed to the further maturation of EDA. In this presentation, examples will be given of the combination of bioassay testing and chemical analysis, focusing on novel fractionation strategies, miniaturized bioassays and the use of compound libraries for the identification of emerging pollutants.